For spots that appeared after braces, which are the most widely studied, the improvement obtained by infiltration was maintained with no measurable change at six months, at one year and then beyond two years (thirty-four months on average), in the same series of patients followed up with a spectrophotometer. These follow-ups involve few people, twenty at the start and eight at the last check-up, and a 2017 systematic review reaches the same conclusion, with the same reservation: the effect has been demonstrated, but long-term data remain limited.
For fluorosis, a randomised trial compared infiltration, in-office whitening and a combination of the two: infiltration came out ahead immediately after treatment, particularly with a longer penetration time; how long the effect lasted was not measured. For hypomineralised enamel, the data are scarcer still, and the response depends on the depth of the lesion.
Day to day, the infiltrated area is cared for like the rest of the tooth: brushing, regular check-ups, and polishing at check-ups if it picks up stains. If whitening is wanted, it is done before infiltration: once in place, the resin does not lighten along with the surrounding enamel.